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KMID : 0617319950050010065
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Journal of Pharmacetical Sceiences Ewha Womans University
1995 Volume.5 No. 1 p.65 ~ p.70
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Effects of Ginkgo biloba Leaf Extracts on the Levels of Neurotransmitters in the Spontaneously Hypertensive Rat Brain
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Abstract
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Effects of Ginkgo biloba leaf extract (GBE) and its components kaempferol-coumaroyl giucosyl rhamnoside (Kc), quercetin-coumaroyl glucosyl rhamnoside (Qc), ginkolide (G) and bilobalide (B) on blood pressure and on the levels of neurotransmitters in the spontaneously hypertensive rat brain were examined. Blood pressure decreased about 10 ㎜Hg after administration of GBE but without significance. The concentration of norepinephrine increased (3 times) and that of DOPAC was decreased (38%) after administration of Qc And 3-MT concentration was increased (36%) by Kc administration in striatum. While Qc administration increased the concentration of Ach (260%) and Ch(29%) significantly, B administration increased Ch concentration in cerebral cortex.
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KEYWORD
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